Association between Low Estimated Glomerular Filtration Rate and Risk of Cerebral Small-Vessel Diseases: A Meta-Analysis

作者：Liu, Yuanyuan; Lv, Pu; Jin, Haiqiang; Cui, Wei; Niu, Chenguang; Zhao, Mingming; Fan, Chenghe; Teng, Yuming; Pan, Bing; Peng, Qing; Luo, Jingjing; Zheng, Lemin^*; Huang, Yining^*

来源：Journal of Stroke and Cerebrovascular Diseases, 2016, 25(3): 710-716.

DOI：10.1016/j.jstrokecerebrovasdis.2015.11.016

• Cerebral small
• vessel diseases
• estimated glomerular filtration rate
• chronic kidney impairment
• meta-analysis

Background: Although chronic kidney disease has been linked to cerebral small-vessel disease (CSVD), a definite relationship between them has not been established. This study assessed whether low estimated glomerular filtration is associated with risk of different subtypes of CSVDs. Methods: Electronic databases were systematically searched for studies reporting an odds ratio of the association between low estimated glomerular filtration and CSVD risk. Sixteen studies, including 10,534 participants, were identified. A fix effects model was applied and odds ratios (ORs) with 95% confidence intervals were presented. Results: Overall, risk of CSVDs was greater in individuals with low estimated glomerular filtration (OR = 2.20). Stratified analyses consistently showed significant associations across different subtypes, with pooled OR being greatest in subjects with silent cerebral infarction (SCI) (OR = 2.71) and cerebral microbleed (OR = 2.70). A pooled estimate of studies showing OR as a continuous variable showed results consistent with the former analysis (OR = .98 per standard deviation decrease) in low estimated glomerular filtration. Conclusions: This study revealed that low estimated glomerular filtration was significantly associated with risk of CSVDs. Low estimated glomerular filtration was most strongly associated with SCI (OR = 2.71) among subtypes of CSVDs.

• 出版日期2016-3
• 单位北京大学