A novel mechanism of regulation of the anti-metastatic miR-31 by EMSY in breast cancer

作者:Mulrane Laoighse; Gallagher William M; O'Connor Darran P*
来源:Breast Cancer Research, 2014, 16(6): 467.
DOI:10.1186/s13058-014-0467-x

摘要

miR-31 is well known as an anti-metastatic microRNA (miRNA) in the context of breast cancer. However, to date the mechanism of regulation of this miRNA has yet to be elucidated. The recent publication by Vire et al. in Molecular Cell [1] demonstrates for the first time that one mechanism of regulation of miR-31 is through the putative oncogene EMSY, whose amplification in breast cancer patients correlates with reduced expression of the miRNA. This regulation is dependent on the DNA-binding transcription factor ETS-1 which recruits EMSY and the histone demethylase KDM5B to the miR-31 promoter, thus repressing its transcription.

  • 出版日期2014

全文