Anti-inflammatory effects of simvastatin on adipokines in type 2 diabetic patients with carotid atherosclerosis

作者：Hu, Yun; Tong, Guoyu; Xu, Wei; Pan, Jiajia; Ryan, Kathy; Yang, Rongze; Shuldiner, Alan R.; Gong, Da-Wei; Zhu, Dalong^*

来源：Diabetes and Vascular Disease Research, 2009, 6(4): 262-268.

DOI：10.1177/1479164109339966

• statin
• anti-inflammation
• adipokines
• atherosclerosis
• type 2 diabetes

Objective: Statins are extensively used for lowering LDL-cholesterol and reducing cardiovascular events. Recent studies have shown that statins have beneficial anti-inflammatory effects. We aimed to determine whether and how adipokines are regulated during statin treatment in type 2 diabetic patients. @@@ Method: In this study, we investigated the changes of CRP and inflammation-related adipokines (SAA, IL-6, TNF alpha and adiponectin) in 23 type 2 diabetic patients with atherosclerosis who received statin therapy, and 20 diabetic patients with atherosclerosis and 14 diabetic patients without atherosclerosis who did not receive statin therapy for a period of three months. @@@ Results: By the end of the simvastatin treatment (40 mg, daily), LDL-cholesterol was decreased by 16.7% and HDL-cholesterol was increased by 31.9%. SAA, CRP, TNF alpha and IL-6 levels were decreased by 31.8%, 66.2%, 53.9% and 14%, respectively and adiponectin was increased by 59.6%, compared with the baseline levels. Interestingly, the decrease of SAA was positively correlated with that of LDL-cholesterol but negatively with HDL-cholesterol during statin treatment. Among the adipokines, the decrease of SAA was positively correlated with TNF alpha (r = 0.50, p = 0.016). @@@ Conclusion: The results suggest that adipokines may be differentially regulated and independent of cholesterol changes and that adipokines may be a mediator, and the adipose tissue may be a target of statins' anti-inflammatory effect.

• 出版日期2009-10
• 单位南京大学