A formal synthesis of (-)-swainsonine from a chiral aziridine

作者：Choi Hwan Geun; Kwon Ji Hye; Kim Jong Chan; Lee Won Koo^*; Eum Heesung; Ha Hyun Joon

来源：Tetrahedron Letters, 2010, 51(25): 3284-3285.

DOI：10.1016/j.tetlet.2010.04.069

A formal synthesis of enantiomerically pure (-)-swainsonine was successfully achieved using intramolecular cyclization of the amino alcohol 4 which was derived from a readily available 1-(R)-alpha-methylbenzylaziridine-2-carboxylic acid (-)-menthol ester 6.

• 出版日期2010-6-23