科研之友
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摘要
Objectives: Quantifying malignancy is difficult. The present study establishes a 10-point scoring system for breast cancer, which directly reflects the chances of 5-year survival. Methods: The 10-point scoring system was based on 5-year overall survival (5Y-OS). The score was set "0" if the 5Y-OS is 100%, and "10" in the case of 0%. The histological types, histological grades, TNM stages, and molecular types were scored separately based on the available literature. The specific score for each index was calculated based on meta-analysis of a cluster of 128 articles obtained from PubMed and CNKI database of China. A final combined score was calculated. Results: Twenty-three histological types of breast cancers were scored between 0 and 6.68 and classified into 4 prognosis groups, such as excellent, good, low-moderate, and poor prognosis. The non-special type (NST) was further scored by histological grade, in a range of 1.12-3.95. Five stages based on TNM were scored as 0.5-6.49. Four molecular types were scored between 1.0 and 2.69. The weight in the combined score was based on the differential capacity. For NST type, TNM staging, histological grade, and molecular type were 0.6, 0.25, and 0.15, respectively. For special types, the histological type and TNM stage each received a score of 0.5. The final score of the excellent prognosis group was 0. Conclusion: The present study established a 10-point scoring system, which could be utilized pathologically.
