ApoA-IV: current and emerging roles in intestinal lipid metabolism, glucose homeostasis, and satiety

作者：Kohan Alison B^*; Wang Fei; Lo Chun Min; Liu Min; Tso Patrick

来源：American Journal of Physiology - Gastrointestinal and Liver Physiology, 2015, 308(6): G472-G481.

DOI：10.1152/ajpgi.00098.2014

• apolipoprotein A-IV (apoA-IV)
• chylomicron
• intestinal lipid transport
• lymph fistula mouse model
• satiety
• diabetes
• obesity
• cardiovascular disease
• glucose homeostasis

Apolipoprotein A-IV (apoA-IV) is secreted by the small intestine on chylomicrons into intestinal lymph in response to fat absorption. Many physiological functions have been ascribed to apoA-IV, including a role in chylomicron assembly and lipid metabolism, a mediator of reverse-cholesterol transport, an acute satiety factor, a regulator of gastric function, and, finally, a modulator of blood glucose homeostasis. The purpose of this review is to update our current view of intestinal apoA-IV synthesis and secretion and the physiological roles of apoA-IV in lipid metabolism and energy homeostasis, and to underscore the potential for intestinal apoA-IV to serve as a therapeutic target for the treatment of diabetes and obesity-related disease.

• 出版日期2015-3-15