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摘要
In the presence of water and triethylamine, a four-component process involving ethyl cyanoacetate, an alpha-methylene carbonyl compound, a primary or a secondary amine, and elemental sulfur leads to efficient room-temperature formation of 2-amino-3-carboxamide derivatives of thiophene in short time periods. The products, which precipitate from the reaction mixtures, are easily obtained by simple filtration and recrystallization from ethyl acetate/hexanes.
- 出版日期2014
