Toll-like receptor 3 polymorphism is not associated with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in the Chinese

作者：Cheng, Y.; Li, M. W.; Li, H. P.; Zeng, W. T.; Zhou, P.; Huang, L. Z.; Li, X. X.^*; Sun, Y. Y.

来源：Genetics and Molecular Research, 2014, 13(1): 302-309.

DOI：10.4238/2014.January.17.15

• Neovascular age-related macular degeneration
• TLR3
• Polypoidal choroidal vasculopathy
• Single nucleotide polymorphism

Toll-like receptor 3 (TLR3) variants in mainland northern Chinese patients with polypoidal choroidal vasculopathy (PCV) and neovascular age-related macular degeneration (nAMD) were investigated. The complete genes of TLR3, including all exons and the promoter region, were assessed using direct sequencing technology of 284 unrelated mainland northern Chinese individuals: 96 nAMD patients, 92 PCV patients, and 96 controls. Six single nucleotide polymorphisms were identified: rs5743303, rs5743305, rs5743312, rs3775291, rs3775290, and rs6830345. The distribution of TLR3 genotypes for nAMD and PCV was not significantly different compared with normal controls. This study indicates that the TLR3 gene polymorphism is not associated with nAMD and PCV in northern Chinese patients.

• 出版日期2014
• 单位北京大学; 复旦大学