Coordination Properties of 3-Functionalised beta-Cyclodextrins: Thermodynamic Stereoselectivity of Copper(II) Complexes of the 3-Histamine Derivative and Its Exploitation in Ligand-Exchange Capillary Electrophoresis

作者：Giuffrida Alessandro; Cucinotta Vincenzo; Maccarrone Giuseppe; Messina Marianna; Rizzarelli Enrico; Vecchio Graziella^*

来源：European Journal of Inorganic Chemistry, 2014, 2014(2): 377-383.

DOI：10.1002/ejic.201301015

• Amino acids
• Cyclodextrins
• Copper
• Thermodynamics
• Chirality

A histamine derivative of -cyclodextrin functionalised at the secondary rim was synthesised and characterised by optical and NMR spectroscopy. Its binary systems both with proton and copper(II) were thermodynamically characterised through pH-metric potentiometry. In addition, the ternary systems with the enantiomers of tryptophan, phenylalanine and alanine were investigated. Thermodynamic stereoselectivity was observed for both the tryptophan and phenylalanine enantiomers. The properties of the synthesised cyclodextrin derivative as a chiral selector were verified in chiral ligand-exchange capillary electrophoresis (CLECE) towards the enantiomeric pairs of some amino acids.

• 出版日期2014-1