科研之友
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摘要
beta-Amino alcohols are bioactive molecules, used also as catalysts in asymmetric C-C bond formation. While asymmetric synthesis has been the preferred route for their preparation, there was always been a need to develop a facile methodology involving environmentally friendly transformations. Masked amines in the form of phthalimide alcohols, prepared via a fast coupling reaction in an ionic liquid as a reusable reaction media together with reduction and an efficient biocatalytic resolution, offer a green methodology for enantiomerically pure products ( ee > 99%, 50 g L-1).
- 出版日期2007
