Building and validation of a prognostic model for predicting extracorporeal circuit clotting in patients with continuous renal replacement therapy

作者：Fu, Xia; Liang, Xinling; Song, Li; Huang, Huigen; Wang, Jing; Chen, Yuanhan; Zhang, Li; Quan, Zilin; Shi, Wei^*

来源：International Urology and Nephrology, 2014, 46(4): 801-807.

DOI：10.1007/s11255-014-0682-5

• Continuous renal replacement therapy
• Empirical formula
• Predictive model
• Circuit clotting
• Circuit life span

Purpose To develop a predictive model for circuit clotting in patients with continuous renal replacement therapy (CRRT).
Methods A total of 425 cases were selected. 302 cases were used to develop a predictive model of extracorporeal circuit life span during CRRT without citrate anticoagulation in 24 h, and 123 cases were used to validate the model. The prediction formula was developed using multivariate Cox proportional-hazards regression analysis, from which a risk score was assigned.
Results The mean survival time of the circuit was 15.0 +/- 1.3 h, and the rate of circuit clotting was 66.6 % during 24 h of CRRT. Five significant variables were assigned a predicting score according to the regression coefficient: insufficient blood flow, no anticoagulation, hematocrit >= 0.37, lactic acid of arterial blood gas analysis <= 3 mmol/L and APTT < 44.2 s. The Hosmer-Lemeshow test showed no significant difference between the predicted and actual circuit clotting (R-2 = 0.232; P = 0.301).
Conclusions A risk score that includes the five above-mentioned variables can be used to predict the likelihood of extracorporeal circuit clotting in patients undergoing CRRT.

• 出版日期2014-4
• 单位广东省人民医院; 南方医科大学