Actigraphy in patients with treatment-resistant depression undergoing electroconvulsive therapy

作者：Winkler Dietmar^*; Pjrek Edda; Lanzenberger Rupert; Baldinger Pia; Eitel Daniel; Kasper Siegfried; Frey Richard

来源：Journal of Psychiatric Research, 2014, 57: 96-100.

DOI：10.1016/j.jpsychires.2014.06.006

• Treatment-resistant depression
• ECT
• Activity
• Sleep wake cycle
• Chronobiology
• Actigraphic measurements

Depressive disorder is frequently accompanied by changes in psychomotor activity and disturbances of the sleep wake cycle. The chronobiological effects of electroconvulsive therapy (ECT) in patients with treatment-resistant depression (TRD) are largely unknown. The objective of the current study was to measure the influence of ECT on patients%26apos; activity and sleep. 15 patients with unipolar TRD were treated with ECT. Activity levels were measured with wrist actigraphy before and after ECT. Remission rate (score on the 17-item Hamilton Depression Rating Scale lower than 8 points) was 40.0%. Remitters had increases of 56.0% on light activity, 49.8% on total activity, and 70.2% on circadian amplitude, while there was no significant change of these variables in subjects who did not experience remission. The circadian acrophase and actigraphic sleep-parameters were not significantly affected by treatment.

• 出版日期2014-10