Acute effects of intravenous cocaine administration on serum concentrations of ghrelin, amylin, glucagon-like peptide-1, insulin, leptin and peptide YY and relationships with cardiorespiratory and subjective responses

作者：Bouhlal Sofia; Ellefsen Kayla N; Sheskier Mikela B; Singley Erick; Pirard Sandrine; Gorelick David A; Huestis Marilyn A; Leggio Lorenzo^*

来源：Drug and Alcohol Dependence, 2017, 180: 68-75.

DOI：10.1016/j.drugalcdep.2017.07.033

• Appetitive hormones
• IV cocaine administration
• Cardiorespiratory responses
• Subjective responses

Background: Food intake and use of drugs of abuse like cocaine share common central and peripheral physiological pathways. Appetitive hormones play a major role in regulating food intake; however, little is known about the effects of acute cocaine administration on the blood concentrations of these hormones in cocaine users.
Methods: We evaluated serum concentrations of six appetitive hormones: ghrelin (total and acyl-ghrelin), amylin, glucagon-like peptide-1 (GLP-1), insulin, leptin and peptide YY (PYY), as well as acute cardiorespiratory and subjective responses of 8 experienced cocaine users who received 25 mg intravenous (IV) cocaine.
Results: Serum concentrations of GLP-1 (p = 0.014) and PYY (p = 0.036) were significantly decreased one hour following IV cocaine administration; there was a trend towards a decrease for insulin (p = 0.055) and amylin (p = 0.063) concentrations, while no significant IV cocaine effect was observed for ghrelin (total or acyl-ghrelin) or leptin concentrations (p's >> > 0.5). We also observed associations between hormone concentrations acutely affected by IV cocaine (GLP-1, PYY, insulin, amylin) and some cocaine-related cardiorespiratory and subjective responses (e.g., increased heart and respiratory rates; feeling high and anxious).
Discussion: These findings show a significant effect of acute IV cocaine administration on some appetitive hormones and suggest potential associations between these hormones and cocaine-related cardiorespiratory and subjective responses. Additional research is needed to further investigate the potential mechanisms underlining these associations.

• 出版日期2017-11-1
• 单位NIH