科研之友
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摘要
We evaluated in vivo the mu-opioid system during spontaneous episodic migraine headaches. Seven patients were scanned at different phases of their migraine using positron emission tomography with the selective mu-opioid receptor (mu OR) radiotracer [11C] carfentanil. In the ictal phase, there was mu OR activation in the medial prefrontal cortex, which was strongly associated with the mu OR availability level during the interictal phase. Furthermore, mu-opioid binding changes showed moderate negative correlation with the combined extension and severity of the attacks. These results indicate for the first time that there is high mu OR activation in the migraineurs' brains during headache attacks in response to their pain.
- 出版日期2014-6
