Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G: A possible role in the resistance to HIV of HIV-exposed seronegative individuals

作者：Biasin Mara; Piacentini Luca; Lo Caputo Sergio; Kanari Yasuyoshi; Magri Giuliana; Trabattoni Daria; Naddeo Valentina; Lopalco Lucia; Clivio Alberto; Cesana Eugenio; Fasano Francesca; Bergamaschi Cristina; Mazzotta Francesco; Miyazawa Masaaki; Clerici Mario^*

来源：Journal of Infectious Diseases, 2007, 195(7): 960-964.

DOI：10.1086/511988

Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G), a human cytidine deaminase, is a potent inhibitor of HIV replication. To explore a possible role of this protein in modulating in vivo susceptibility to HIV infection, we analyzed APOBEC3G expression in HIV-exposed seronegative individuals, HIV-seropositive patients, and healthy control subjects. The results showed that the expression of APOBEC3G is significantly increased in peripheral blood mononuclear cells (PBMCs)-mainly CD14(+) cells-and in cervical tissues of HIV-exposed seronegative individuals. Higher APOBEC3G expression correlated with a reduced susceptibility of PBMCs to in vitro infection with the HIV-1(Ba-L) R5 strain. APOBEC3G could be important in modulating in vivo susceptibility to sexually transmitted HIV infection.

• 出版日期2007-4-1