Artesunate-amodiaquine efficacy in Congolese children with acute uncomplicated falciparum malaria in Brazzaville

作者：Ndounga Mathieu^*; Mayengue Pembe Issamou; Casimiro Prisca Nadine; Loumouamou Dieudonne; Basco Leonardo K; Ntoumi Francine; Brasseur Philippe

来源：Malaria Journal, 2013, 12(1): 53.

DOI：10.1186/1475-2875-12-53

• Drug resistance
• Artemisinin
• Combination therapy
• Chloroquine
• Drug efficacy
• Congo-Brazzaville

Background: Congo-Brazzaville adopted artemisinin-based combination therapy (ACT) in 2006. Artesunate-amodiaquine (AS + AQ) and artemether-lumefantrine are the first-line and second-line anti-malarial drugs to treat uncomplicated Plasmodium falciparum malaria, respectively. The baseline efficacy of AS + AQ was evaluated from February to August 2005 in patients living in Brazzaville, the capital city of the Republic of Congo. %26lt;br%26gt;Methods: One hundred and ninety-seven patients (96 %26lt;= 5 years old and 101 %26gt; 5 years old, including adults) were recruited in a non-randomized study, treated under supervision with AS + AQ, and were followed up for 28 days in accordance with the 2003 World Health Organization protocol. Plasmodium falciparum recrudescent isolates from day 7 to day 28 were compared to pretreatment isolates by polymerase chain reaction (PCR) to distinguish between re-infection and recrudescence. %26lt;br%26gt;Results: The overall efficacy of AS + AQ after PCR correction on day 28 was 94.4%. An adequate clinical and parasitological response was observed in 94.3% and 94.4% of children aged %26lt;= 5 years old and those aged %26gt; 5 years old (including adults), respectively. The main reported adverse events were dizziness, vomiting, diarrhoea, pruritus, headache, anorexia, and abdominal pain. %26lt;br%26gt;Conclusion: This study has shown the high efficacy of AS + AQ in Congolese patients of all ages with acute uncomplicated falciparum malaria and serves as the baseline efficacy and tolerance of this ACT in Brazzaville.

• 出版日期2013-2-5