An Effective Personalized Approach to a Rare Tumor: Prolonged Survival in Metastatic Pancreatic Acinar Cell Carcinoma Based on Genetic Analysis and Cell Line Development

作者：Armstrong Matthew D; Von Hoff Daniel; Barber Bruce; Marlow Laura A; von Roemeling Christina; Cooper Simon J; Travis Patrick; Campbell Elizabeth; Paz Fumagalli Ricardo; Copland John A; Colon Otero Gerardo^*

来源：Journal of Cancer, 2011, 2: 142-152.

DOI：10.7150/jca.2.142

• acinar cell pancreatic cancer
• prolonged survival
• personalized medicine
• cell line

Acinar cell carcinoma of the pancreas is an uncommon malignancy, accounting for less than 1% of all pancreatic neoplasms. Because of its rarity, only a few retrospective studies are available to help guide management. We report the case of a patient with metastatic ACC who achieved prolonged survival as a result of personalized treatment designed in part on the basis of molecular and in-vitro data collected on analysis of the tumor and a cell line developed from the liver metastasis. To our knowledge, this represents the first human cell line of ACC. The molecular findings on this case and this patient's cell line may be of use in the management of future cases of this rare tumor and allow the identification of potential novel targets for the effective treatment of this disease.

• 出版日期2011