Hydrogels of dihydroxypropyl chitosan crosslinked with irradiation at paste-like condition

作者：Zhao Long^*; Mitomo Hiroshi

来源：Carbohydrate Polymers, 2009, 76(2): 314-319.

DOI：10.1016/j.carbpol.2008.10.030

• Dihydroxypropyl chitosan
• Hydrogel
• Radiation
• Swelling
• Biodegradability

In present study, a series of environmentally friendly hydrogel films were prepared from dihydroxypropyl chitosan (DHP-chitosan) using irradiation technique without any bifunctional crosslinking compounds. DHP-chitosan irradiated at high concentrated solution state (more than 10%, paste-like state) was found to introduce crosslinking structure. Crosslinking behavior, mechanical property, morphology, and swelling behavior of the hydrogel films were studied. It has been found that a concentration of 40% solution is the most effective for crosslinking. The hydrogel films of DHP-chitosan exhibited controllable mechanical property and typically pH-sensitive character in their swelling behavior. A preliminary biodegradation study confirmed that DHP-chitosan hydrogels also undergo biodegradation by enzymatic degradation test.

• 出版日期2009-3-17