科研之友
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摘要
Background Local anaesthetics and opioid mixtures are commonly used for the management of postoperative pain. The purpose of this study was to investigate the stability of butorphanol tartrate and ropivacaine hydrochloride in polyolefin bags over a period of 15days, both at room temperature and at 4 degrees C. @@@ Methods Admixtures were assessed initially and for 15days after preparation in polyolefin bags using 0.9% sodium chloride injection as diluents and stored at 4 degrees C and 25 degrees C. The initial concentrations were 50g/mL butorphanol and 1-2mg/mL ropivacaine. The stabilities were determined by visual inspection, pH measurement and high-pressure liquid chromatography assay of drug concentrations. @@@ Results The initial concentrations of butorphanol and ropivacaine were >97% after 15days. The drug mixtures were clear in appearance and no colour change or precipitation was observed. Throughout this period, the pH value remained stable. @@@ Conclusions Butorphanol and ropivacaine in 0.9% sodium chloride injection are stable for at least 15days when stored in polyolefin bags at 4 degrees C and 25 degrees C.
