Adoptive transfer of dendritic cells isolated from helminth-infected mice enhanced T regulatory cell responses in airway allergic inflammation

作者：Liu, J. -Y.; Li, L. -Y.; Yang, X. -Z.; Li, J.; Zhong, G.; Wang, J.; Li, L. -J.; Ji, B.; Wu, Z. -Q.; Liu, H.; Yang, X.; Liu, P. -M.^*

来源：Parasite Immunology, 2011, 33(10): 525-534.

DOI：10.1111/j.1365-3024.2011.01308.x

• asthma
• dendritic cell
• hygiene hypothesis
• regulatory T cell
• Schistosoma japonicum

Our and others' previous studies have shown that Schistosoma japonicum (SJ) infection can inhibit allergic reactions. Moreover, we found that adoptive transfer of dendritic cells (DCs) from inhibited mice showed a similar inhibitory effect on allergy, suggesting a critical role of DCs in SJ-infected mediated inhibition of allergy. In this study, we further examined the mechanism by which DCs contribute to inhibition of allergy. Our results showed that DCs from SJ-infected mice (SJDCs) produced significantly higher levels of IL-10 compared to those from naive control mice (NDCs). Adoptive transfer of SJDCs, unlike NDCs, significantly increased CD4+CD25+Foxp3+ T cells and CD4+CD25+IL-10+ T cells regulatory T-cell responses in vivo. This was correlated with significantly reduced production of IL-4 and IL-5 by CD4+ T cells, eotaxin in lung tissues and reduced airway allergic inflammation in the SJDC recipients following allergen sensitization and challenge. These data suggest that helminth infection may induce tolerogenic DCs that can inhibit the development of airway allergic inflammation through enhancing T regulatory cell responses.

• 出版日期2011-10
• 单位天津医科大学