Antimicrobial and Anticancer Efficacy of Antineoplastic Agent Capped Gold Nanoparticles

作者：Selvaraj V^*; Grace A Nirmala; Alagar M; Hamerton I

来源：Journal of Biomedical Nanotechnology, 2010, 6(2): 129-137.

DOI：10.1166/jbn.2010.1115

• Gold Nanoparticles
• Thioguanine
• Au@TG Complex
• Antimicrobial and Anticancer Studies

Synthesis of thioguanine (TG)-capped Au nanoparticles (Au@TG) and their enhanced in vitro antimicrobial and anticancer efficacy against Micrococcus luteus, Staphylococcus aureus, Pseudomonas aeruginosa, E-Coli, Aspergillus fumigatus, Aspergillus niger and Hep2 cancer cell (Human epidermiod cell) have been reported. The nature of binding between 6-TG and the gold nanoparticles via complexation is investigated using ultraviolet visible spectrum, cyclic voltammetry, transmission electron microscopy, fluorescence and Fourier transform infrared (FT-IR) spectroscopy. The present experimental studies suggests that Au@TG are more potential than TG towards antimicrobial and anticancer activities. Hence, gold nanoparticles have the potential to be used as effective carriers for anticancer drug.

• 出版日期2010-4