科研之友
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摘要
Purpose: To investigate whether 1H-MRSI can be used to predict the proliferative activity of prostate cancer. @@@ Materials and methods: Thirty-eight patients with prostate cancer (PCa) and thirty-three patients with benign prostate hyperplasia (BPH) were included in this study. Patients were examined in supine position using a 1.5T superconducting magnetic scanner equipped with a pelvic phased-array multi-coil and CSI-3D-PROSTATE sequence. Commercial software was used to acquire and process MR spectroscopic imaging data. Mean (Cho + Cr)/Cit ratios of PCa, BPH, and peripheral zone (PZ) were calculated. Cellularity of PCa was recorded based on hematoxylin and eosin staining. PCNA was detected using immunohistochemical techniques. @@@ Results: The mean (Cho + Cr)/Cit ratio of the peripheral zone (0.38 +/- 0.09) was lower than that of BPH (0.51 +/- 0.19) (P< 0.05). The average value of (Cho + Cr)/Cit ratio of prostate cancer was 3.98 +/- 0.12. The (Cho + Cr)/Cit ratio of prostate cancer was higher than that of the peripheral zone and BPH (P< 0.05). The cellularity and PCNA LI of prostate cancer were 12.90 +/- 4.07% and 72.1 +/- 19.01%, respectively. The (Cho + Cr)/Cit ratio of prostate cancer positively correlated with tumor cellularity (r = 0.582, P = 0.027) and PCNA LI (r = 0.495, P = 0.022). @@@ Conclusion: The (Cho + Cr)/Cit ratio of PCa can reveal the differences in proliferative activity between PCa and BPH. MRSIs are therefore able to predict the proliferative rate of variously differentiated prostate cancers.
