科研之友
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摘要
Gastric inhibitory polypeptide (GIP) is a gut derived peptide with multiple emerging physiological actions. Effects of pregnancy and lactation on GIP secretion and related gene expression were studied in Wistar rats. Pregnancy moderately increased feeding (p%26lt;0.05), whilst lactation substantially increased food intake (p%26lt;0.01 to p%26lt;0.001). Circulating GIP was unchanged during pregnancy, but non-fasting plasma glucose was significantly (p%26lt;0.01) decreased and insulin increased (p%26lt;0.05). Lactation was associated with elevated circulating GIP concentrations (p%26lt;0.001) without change of glucose or insulin. Oral glucose resulted in a significantly (p%26lt;0.001) decreased glycaemic excursion despite similar glucose-induced GIP and insulin concentrations in lactating rats. Pregnant rats had a similar glycaemic excursion but exhibited significantly lowered (p%26lt;0.05) GIP accompanied by elevated (p%26lt;0.001) insulin levels. Pregnant rats exhibited increased (p%26lt;0.001) islet numbers and individual islet areas were enlarged (p%26lt;0.05). There were no significant differences in islet alpha-cell areas, but all groups of rats displayed co-expression of glucagon and GIP in alpha-cells. Lactating rats exhibited significantly (p%26lt;0.01) increased intestinal weight, whereas intestinal GIP stores were significantly (p%26lt;0.01) elevated only in pregnant rats. Gene expression studies in lactating rats revealed prominent (p%26lt;0.01 to p%26lt;0.001) increases in mammary gland expression of genes involved in energy turnover, including GIP-R. GIP was present in intestines and plasma of 17 day old foetal rats, with substantially raised circulating concentrations in neonates throughout the period of lactation/suckling. These data indicate that changes in the secretion and action of GIP play an important role in metabolic adaptations during pregnancy and especially lactation.
- 出版日期2013-11-13
