Advances in the Use of Supercritical Fluids for the Production of Poly(alpha-hydroxyester) Particles Incorporating Bioactive Agents

作者：Sacchetin Priscila S C; Rosa Paulo T V; Moraes Angela M^*

来源：Journal of Biomaterials and Tissue Engineering, 2013, 3(1): 89-107.

DOI：10.1166/jbt.2013.1073

• Supercritical Fluids
• Nanoparticles
• Microparticles
• Polymers
• Liposomes
• Active Agents

Encapsulation of active agents in particulate systems has several advantages over other types of therapeutic formulations, since these systems allow the controlled release of the agent as well as preventing from being degraded prematurely in the body. Nano and microparticles are particularly attractive for this purpose, being capable of releasing active agents through different delivery routes, such as intravenous, subcutaneous, pulmonary, and oral ones. Supercritical fluid technology has proved to be a viable alternative for their preparation, being able to efficiently promote the nucleation and growth of particles from polymers and lipids, among other materials, designed specifically for pharmaceutical applications. Different approaches can be used for the production of particles via supercritical fluid technology, depending on the choice of vehicle material and also on the physicochemical characteristics of the active agent. The supercritical fluid can be used as a solvent, as an anti-solvent or as a solute, efficiently resulting in particles with high active agent load, narrow size distribution and through processes involving low amounts of organic solvents. This technology is gaining strength in the pharmaceutical area and recent advances will be discussed in this work, focusing more particularly on particles constituted of biocompatible poly(alpha-hydroxyesters).

• 出版日期2013-2