A Facile Synthesis of 4,6-Dimethoxy-2-methylsulfonylpyrimidine

作者：Xu, Defeng^*; Zhu, Zhiling; Xu, Hui; Wang, Ziqiao

来源：Asian Journal of Chemistry, 2014, 26(1): 313-314.

DOI：10.14233/ajchem.2014.16083

• Nucleophilic substitution
• Oxidation
• 4,6-Dimethoxy-2-methyl sulfonylpyrimidine
• 2-Chloro-4,6-dimethoxypyrimidine

A facile and efficient synthesis of 4,6-dimethoxy-2-methylthiopyrimidine can be achieved by nucleophilic substitution of 2-chloro-4,6dimethoxypyrimidine with sodium methyl mercaptide for a 95.6 % yield. 4,6-Dimethoxy-2-methylsulfonylpyrimidine can be produced via oxidation using hydrogen peroxide in the presence of sodium tungstate dihydrate in a 95 % yield.

• 出版日期2014-1
• 单位常州大学