Application of Horner-Wadsworth-Emmons olefination for the synthesis of granulatamide A, its E isomer and other amides of tryptamine

作者：Pakhare Deepali; Kusurkar Radhika

来源：New Journal of Chemistry, 2016, 40(6): 5428-5431.

DOI：10.1039/c5nj03533c

Horner-Wadsworth-Emmons (HWE) Z-selective olefination was used for the first synthesis of a naturally occurring cytotoxic tryptamine derivative, granulatamide A. The E-isomer of granulatamide A was synthesized by E-selective HWE olefination. Furthermore, two other tryptamine derived amides were prepared by using the same strategy.

• 出版日期2016-6-1