A novel lipase enzyme panel exhibiting superior activity and selectivity over lipase B from Candida antarctica for the kinetic resolution of secondary alcohols

作者:O'Neill Maeve; Beecher Denis; Mangan David*; Rowan Andrew S; Monte Agnieszka; Sroka Stefan; Modregger Jan; Hundle Bhupinder; Moody Thomas S
来源:Tetrahedron: Asymmetry , 2012, 23(8): 583-586.
DOI:10.1016/j.tetasy.2012.03.013

摘要

A novel, commercially available lipase enzyme panel performing kinetic bioresolutions of a number of secondary alcohols is reported. The secondary alcohols that have been chosen are known from the literature to be particularly challenging substrates to resolve. Following initial screening, four co-solvents were investigated for each lead enzyme in an effort to assess their tolerance to common organic solvents. The superiority of these novel enzymes over lipase B from Candida antarctica (CALB) has been demonstrated.

  • 出版日期2012-4-30