A DNA fragment from Streptomyces peucetius activates biosynthesis of actinorhodin in Streptomyces lividans and daunomycin in the original strain

作者：Rosabal G; Rodriguez C; del Sol R; Planas S; Vallin C; Malpartida F^*

来源：Biotechnology Letters, 2001, 23(4): 289-293.

DOI：10.1023/A:1005634423478

• anthracycline
• antibiotic
• doxorubicin
• pleiotropic activation

A chromosomal DNA fragment from Streptomyces peucetius SGF-107 (a producer of daunomycin) which activates the biosynthesis of two polyketide antibiotics, daunomycin and actinorhodin, has been cloned and sequenced. Partial DNA sequencing of the activating fragment revealed the presence of two open reading frames whose deduced products exhibit similarities with that of other known transcriptional regulators of the MarR and ArsR family, respectively.

• 出版日期2001-2