Central Nervous System Involvement of Epstein Barr Virus Associated Lymphoproliferative Disorder in a Child with Acute Lymphoblastic Leukemia: Successful Treatment with Rituximab and Interferon-Alpha

作者：Atabay Berna; Turker Meral; Ozturk Can; Sutcuoglu Sumer; Oniz Haldun; Ozer Esra Arun^*

来源：Turkish Journal of Hematology, 2013, 30(1): 58-62.

DOI：10.4274/tjh.2011.0047

• Epstein-Barr virus
• Lymphoproliferative disorder
• Rituximab
• Children
• Leukemia

Central nervous system (CNS) involvement of Epstein-Barr virus (EBV)-associated lymphoproliferative disease is a rare and serious complication in children with leukemia. Although rituximab therapy seems to be promising in these cases, persistent hypogammaglobulinemia may appear after treatment due to complete depletion of normal B lymphocytes in the peripheral blood. Here we report isolated CNS involvement of EBV-associated lymphoproliferative disorder in a 4-year-old boy with acute leukemia. The patient was treated with rituximab and interferon alpha; however, persistent hypogammaglobulinemia developed as a complication. Given the rarity of the complication in children receiving these agents, our experience with such a case may be helpful to others.

• 出版日期2013-3