A comprehensive assessment of outcomes in pregnancies conceived by in vitro fertilization/intracytoplasmic sperm injection

作者：Wen, Shi Wu^*; Leader, Arthur; White, Ruth Rennicks; Leveille, Marie-Claude; Wilkie, Valerie; Zhou, Jia; Walker, Mark C.

来源：European Journal of Obstetrics & Gynecology and Reproductive Biology, 2010, 150(2): 160-165.

DOI：10.1016/j.ejogrb.2010.02.028

• In vitro fertilization
• Intracytoplasmic sperm injection
• Congenital heart defects
• Obesity
• Canada

Objective: To assess the association between in vitro fertilization (IVF) with or without intracytoplasmic sperm injection (ICSI) and adverse birth outcomes.
Study design: Retrospective cohort study involved IVF/ICSI patients who were treated in the Ottawa Fertility Centre from 1996 to 2005 with a viable pregnancy (>20 weeks of gestation) and mothers who conceived naturally.
Results: Eleven of the 1044 infants conceived with IVF/ICSI (1.1%) and 7 of the 1910 naturally conceived infants (0.4%) had congenital heart defects (P < 0.01). Five of the 138 infants (3.6%) born to mothers with a body mass index > 30 and conceived by IVF/ICSI had congenital heart defects, compared with none in the 240 infants born to mothers with a body mass index > 30 and conceived naturally (P < 0.01).
Conclusion: Infants conceived with use of IVF/ICSI have three times as high a risk of a congenital heart defect as naturally conceived infants.

• 出版日期2010-6
• 单位中南大学