An efficient protocol for the synthesis of benzoheterocyclic compounds via solid-state melt reaction (SSMR)

作者：Bakthadoss Manickam^*; Selvakumar Raman; Srinivasan Jayakumar

来源：Tetrahedron Letters, 2014, 55(42): 5808-5812.

DOI：10.1016/j.tetlet.2014.08.084

• Benzoheterocyclic compounds
• Solid-state melt reaction
• Anti-tumor agents

An efficient protocol for the synthesis of biologically active benzoheterocyclic compounds such as benzothiazoles, benzimidazoles, benzospirothiazoles, and quinoxaline scaffolds have been accomplished via solid state melt reaction (SSMR) with excellent yields. The new protocol does not require any catalyst, solvent, and workup. Two anti-tumor agents have been prepared to demonstrate the application of this new method.

• 出版日期2014-10-15