A label-free biosensor based on organic transistors by using the interaction of mercapto DNA and gold electrodes

作者：Chen, Xiong; Gui, Haiyang; Wei, Bin; Wang, Jun^*

来源：Materials Science in Semiconductor Processing, 2015, 35: 127-131.

DOI：10.1016/j.mssp.2015.02.081

• Organic thin-film transistor
• Biosensor
• DNA
• Pentacene

Organic thin-film transistors (OTFTs) with Au electrodes were successfully used as transducers for label-free deoxyribonucleic acid (DNA) sensors. Single-strand DNA (ssDNA), perfectly-matched double-strand DNA (dsDNA) and mis-matched DNA were immobilized on the surface of the source/drain electrodes of three OTFT devices respectively. The ssDNA molecules with mercapto group (-SH) can be well immobilized on the surface of Au electrode by chemical bond between -SH and Au atom. According to the significant difference in channel current, which was attributed to the changed contact resistances by introducing different DNA molecules on Au electrode, ssDNA, matched-dsDNA and mismatched-dsDNA were differentiated successfully in the experiments. The results may provide a promising approach for detecting DNA specificity and hybridization with label-free.

• 出版日期2015-7
• 单位上海大学