Adherence and persistence associated with an appointment-based medication synchronization program

作者：Holdford David A^*; Inocenclo Timothy J

来源：Journal of the American Pharmacists Association, 2013, 53(6): 576-583.

DOI：10.1331/JAPhA.2013.13082

• Community pharmacy services
• medication adherence
• chronic disease
• pharmacies

Objective: To assess the impact of an appointment-based medication synchronization (ABMS) program on medication adherence and persistence with chronic medications. %26lt;br%26gt;Design: Quasiexperimental study in which study patients were matched with control patients. %26lt;br%26gt;Setting Rural pharmacies in the Midwestern United States between June 30, 2011, and October 31, 2012. %26lt;br%26gt;Patients: Individuals receiving at least two refills for one of six categories of medications to treat chronic diseases (i.e., angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, beta blockers, dihydropyridine calcium channel blockers, thiazide diuretics, metformin, statins). %26lt;br%26gt;Intervention: Patients in the ABMS program were compared with control patients receiving usual care. %26lt;br%26gt;Main outcome measures: 1-year adherence rates using proportion of days covered (PDC) and 1-year nonpersistence rates. %26lt;br%26gt;Results: Depending on the drug class, patients enrolled in the medication synchronization program (n = 47-81) had adherences rates of 66.1% to 75.5% during 1 year versus 37.0% to 40.8% among control patients. Program patients had 3.4 to 6.1 times greater odds of adherence compared with control patients. Control patients were 52% to 73% more likely to stop taking their chronic medications over 1 year. %26lt;br%26gt;Conclusion: An ABMS program in community pharmacies was associated with improved patient adherence and reduced likelihood of nonpersistence.

• 出版日期2013-12