Anti-inflammatory effects of fatty acids isolated from Chromolaena odorata

作者：Tran Thi Hong Hanh; Dan Thi Thuy Hang; Chau Van Minh; Nguyen Tien Dat^*

来源：Asian Pacific Journal of Tropical Medicine, 2011, 4(10): 760-763.

• Chromolaena odorata
• Asteraceae
• Fatty acid
• NF- kappa B
• Nitric oxide

Objective: To identify inhibitors of nitric oxide Production and NF- kappa B activity from Chromolaena odorata (C. odorata). Methods: The compounds isolated from the aerial parts of C. odorata by bioassay-guided fractionation were investigated for their inhibitory effects on the NO production and NF- kappa B activity in LPS-stimulated RAW264.7 cells Results: Six fatty acids (S)-coriolic acid (1), (S)-coriolic acid methyl ester (2), (5)-15,16-didehydrocoriolic acid (3), (S)-15,15-didehydrocoriolic acid methyl ester (4), linoleamide (5) and linolenamide (6) were isolated. All compounds inhibited the NO production at concentrations consistent with those required for NF- kappa B inhibition. Compound 2 was the most active with the IC50 values of 5.22 and 5.73 mu M. The addition of a double bond in the fatty chain decreased the inhibitory effects while the methyl esterification increased the activities. Conclusions: The fatty acid components in C. odorata with NF- kappa B inhibitory activity could explain the anti-inflammation Property of this Plant in traditional medicine. This study could also contribute to the better use of C. odorata for human health care.

• 出版日期2011-10