High-resolution time-of-flight mass spectrometry combined with high-performance liquid chromatography for detection and determination of quinolones and sulfonamides in foods

作者：Amelin V G^*; Korotkov A I; Volkova N M

来源：Journal of Analytical Chemistry, 2015, 70(14): 1629-1634.

DOI：10.1134/S1061934815140026

• quinolone antibiotics (fluoroquinolones)
• sulfonamides
• food
• high-performance liquid chromatography
• high-resolution time-of-flight mass spectrometry

High-resolution time-of-flight mass spectrometry combined with high-performance liquid chromatography is proposed for the detection and determination of trace amounts of 23 quinolones (fluoroquinolones) and a number of sulfonamides in food. The samples were prepared using a simplified and rapid sample preparation procedure. The analytical ranges for quinolones and sulfonamides are from 0.05 (1) to 1000 (2000) A mu g kg(-1). We developed a procedure for the identification and determination of the detected quinolones by the standard addition method. The relative standard deviation of the results is less than 10%.

• 出版日期2015-12