A synthetic ditryptophan conjugate that rescues bacteria from mercury toxicity through complexation

作者：Mondal Sudipta; Swaroop Shiv; Gurunath Ramanathan^*; Verma Sandeep

来源：Tetrahedron Letters, 2010, 51(47): 6111-6115.

DOI：10.1016/j.tetlet.2010.09.047

• Tryptophan conjugate
• Mercury sequestration
• Mercury sensing
• Fluorescence
• Self assembly

The synthesis of ditryptophan-pyridine conjugates and their binding to mercury ions is described. Conjugate 3 shows an excellent ability to sequester mercury from solution and rescue bacterial growth in a concentration-dependent survival assay. It is proposed that such compounds, composed primarily of bioessential/biodegradable components, could be potentially used as sequestrating agents for the removal of Hg(II) ions in detoxification strategies.

• 出版日期2010-11-24