Diethylcarbamazine Attenuates the Development of Carrageenan-Induced Lung Injury in Mice

作者：Ribeiro Edlene Lima^*; de Souza Barbosa Karla Patricia; Fragoso Ingrid Tavares; Matos Donato Mariana Aragao; dos Santos Gomes Fabiana Oliveira; da Silva Bruna Santos; Silva Amanda Karolina Soares e; Santos Rocha Sura Wanessa; da Silva Junior Valdemiro Amaro; Peixoto Christina Alves

来源：Mediators of Inflammation, 2014, 2014: 105120.

DOI：10.1155/2014/105120

Diethylcarbamazine (DEC) is an antifilarial drug with potent anti-inflammatory properties as a result of its interference with the metabolism of arachidonic acid. The aim of the present study was to evaluate the anti-inflammatory activity of DEC in a mouse model of acute inflammation (carrageenan-induced pleurisy). The injection of carrageenan into the pleural cavity induced the accumulation of fluid containing a large number of polymorphonuclear cells (PMNs) as well as infiltration of PMNs in lung tissues and increased production of nitrite and tumor necrosis factor-alpha and increased expression of interleukin-1 beta, cyclooxygenase (COX-2), and inducible nitric oxide synthase. Carrageenan also induced the expression of nuclear factor-kappa B. The oral administration of DEC (50 mg/Kg) three days prior to the carrageenan challenge led to a significant reduction in all inflammation markers. The present findings demonstrate that DEC is a potential drug for the treatment of acute lung inflammation.

• 出版日期2014