Antioxidative and hepatoprotective effects of enzymatic and acidic-hydrolysis of Pleurotus geesteranus mycelium polysaccharides on alcoholic liver diseases

作者：Song, Xinling; Liu, Zhonghai; Zhang, Jianjun; Zhang, Chen; Dong, Yuhan; Ren, Zhenzhen; Gao, Zheng; Liu, Min; Zhao, Huajie; Jia, Le^*

来源：Carbohydrate Polymers, 2018, 201: 75-86.

DOI：10.1016/j.carbpol.2018.08.058

• Antioxidant and hepatoprotection
• Characterization
• Alcoholic liver diseases
• Enzymolysis and acidolysis
• Pleurotus geesteranus polysaccharides

The present work investigated the antioxidant and hepatoprotective effects of acidic- and enzymatic-hydrolysis mycelium polysaccharide (AcMPS and EnMPS) from Pleurotus geesteranus on alcoholic liver disease (ALD) mice. The animal studies demonstrated that the polysaccharides had potential effects reflected by remitting alcoholic hepatitis, reducing lipid accumulation, preventing oxidative stress, improving inflammatory symptoms, and alleviating the liver functions by histopathologic observation. Results showed that AcMPS (yield of 84%) was composed of L-Rha, D-Rib, L-Ara, D-Glc, D-Man and D-Gal with the Mw of 3.49 x 10(4 )Da, while EnMPS (yield of 90%) was contained L-Rha, L-Ara, D-Gal and D-Glc with the Mw of 3.67 x 10(4) Da. Furthermore, the GC-MS analysis indicated that both AcMPS and EnMPS were beta-pyranoside polysaccharides with the (1 -> 3)- and (1 -> 6)-linkages. The conclusions indicated that AcMPS and EnMPS could be used as natural drugs for preventing the ALD, and providing underlying hepatoprotective mechanisms, pharmaceutically.

• 出版日期2018-12-1
• 单位山东农业大学