High serum S100A8/A9 levels and high cardiovascular complication rate in type 2 diabetics with ultrasonographic low carotid plaque density

作者：Hirata Ayumu; Kishida Ken^*; Nakatsuji Hideaki; Hiuge Shimizu Aki; Funahashi Tohru; Shimomura Iichiro

来源：Diabetes Research and Clinical Practice, 2012, 97(1): 82-90.

DOI：10.1016/j.diabres.2012.01.026

• S100A8/A9 complex
• Adiponectin
• Vulnerable blood
• Vulnerable plaque

Aims: S100A8/A9 complex is an inflammation-associated biomarker, which binds toll-like receptor 4 and was associated with the receptor for advanced glycation end-products. S100A8 and S100A9 were accumulated in atherosclerotic lesions. High serum levels of S100A8/A9 are associated with acute coronary syndrome and atherosclerosis in type 2 diabetes mellitus (T2DM). However, association between serum S100A8/A9 levels and vulnerable plaque remains unclear. The present study investigated the relation between serum S100A8/A9 levels and relative plaque density (RPD) of the carotid artery determined by ultrasonography in T2DM.
Methods: The study subjects were 72 consecutive T2DM outpatients (males/females = 42/30), who underwent the carotid artery ultrasonography. RPD in the carotid artery was calculated by the formula; RPD = [density of the carotid plaque/density of vessel lumen]. Serum levels of adiponectin and S100A8/A9 were measured.
Results: The median RPD was 2.1. Patients with low RPD (<= 2.1) were significantly more likely to have metabolic syndrome, nephropathy, coronary artery disease, and peripheral artery disease, and higher levels of S100A8/A9, S100A8/A9-to-adiponectin ratio, and uric acid, compared to those with high RPD (> 2.1).
Conclusions: T2DM patients with low RPD had higher prevalence of metabolic syndrome, cardiovascular diseases and higher serum S100A8/A9 levels, compared to those with high RPD.

• 出版日期2012-7