A Critical Review of the Effects of Hydroxychloroquine and Chloroquine on the Eye

作者：Costedoat Chalumeau Nathalie^*; Dunogue Bertrand; Leroux Gaelle; Morel Nathalie; Jallouli Moez; Le Guern Veronique; Piette Jean Charles; Brezin Antoine P; Melles Ronald B; Marmor Michael F

来源：Clinical Reviews in Allergy and Immunology, 2015, 49(3): 317-326.

DOI：10.1007/s12016-015-8469-8

• Hydroxychloroquine
• Chloroquine
• Antimalarials
• Systemic lupus erythematosus
• Retinopathy
• Drug toxicity

Hydroxychloroquine (HCQ) and chloroquine have been used for more than 50 years to treat systemic lupus erythematosus (SLE) and other rheumatic diseases. In general, these drugs are well tolerated and rarely need to be discontinued because of an adverse systemic reaction. However, both medications can be irreversibly toxic to the retina. A new study indicates that toxicity is not as rare as once believed, but depends critically on daily dosage and duration of use, as well as other risk factors. With attention to dosage and other factors, and with proper screening for early signs of toxicity, HCQ can be prescribed with relative safety even over long periods of time.

• 出版日期2015-12