Italian Advisory Board: sFlt-1/PlGF ratio and preeclampsia, state of the art and developments in diagnostic, therapeutic and clinical management

作者：Di Martino Daniela^*; Cetin Irene; Frusca Tiziana; Ferrazzi Enrico; Fuse Federica; Gervasi Maria Teresa; Plebani Mario; Todros Tullia

来源：European Journal of Obstetrics & Gynecology and Reproductive Biology, 2016, 206: 70-73.

DOI：10.1016/j.ejogrb.2016.08.036

• Angiogenic markers
• Preeclampsia
• Placenta

Extensive research has been published, showing the usefulness of angiogenic markers in both diagnosis and subsequent prediction and management of preeclampsia and placenta-related disorders. Recent evidence provides a helpful cut off for the Elecsys ratio sFlt-1 to PlGF, that predicts preeclampsia development in women with sign and symptoms, before its clinical onset in the short term.
In Europe, no accordance exists for the use of such kind of test in clinical practice; only German guidelines have recently taken it into account, as a diagnostic aid for preeclampsia, in conjunction with other clinical findings.
This panel of Italian experts recently met, in order to review the literature and to promote the evaluation of the clinical utility of Flt-1/PlGF ratio at the Italian country level, as regards: prediction of preeclampsia during the first trimester, prediction or exclusion of new onset or recurrence in patients with risk factors for preeclampsia, triage of patients suffering from gestational hypertension, evaluation of disease severity, prediction of adverse maternal and fetal outcomes.

• 出版日期2016-11