Autophagy in placentas from acidotic newborns: An immunohistochemical study of LC3 expression

作者：Avagliano L^*; Danti L; Doi P; Felis S; Guala M; Locatelli A; Maffeo I; Mecacci F; Plevani C; Simeone S; Bulfamante G P

来源：Placenta, 2013, 34(11): 1091-1094.

DOI：10.1016/j.placenta.2013.09.004

• Autophagy
• Placenta
• LC3
• Neonatal encephalopathy
• Acidosis

Autophagy is an inducible catabolic process activated during compromised conditions, such as hypoxia. Neonatal encephalopathy (NE) is a syndrome of disturbed neurological function. No absolute prognostic indicators are available at birth to identify neonates at high risk to develop NE. %26lt;br%26gt;Immunohistochemical staining with LC3 antibody was performed on 40 placentas from uneventful term singleton pregnancies with umbilical artery pH %26lt;= 7.00 at birth; semi-quantitative analysis was carried-out to estimate autophagy level. 6/40 (15%) neonates developed NE. Placentas from newborns with NE exhibited a higher LC3 expression. Autophagy protein expression in placentas with severe acidosis is a potential marker for poor outcome.

• 出版日期2013-11