A model-based approach for controlling particle size distribution in combined cooling-antisolvent crystallization processes

作者：Ghadipasha N; Romagnoli J A^*; Tronci S; Baratti R

来源：Chemical Engineering Science, 2018, 190: 260-272.

DOI：10.1016/j.ces.2018.06.032

• Crystallization
• Image analysis
• Fokker-Planck Equation
• Particle Size Distribution
• Model-based Control

This article focuses on the design and implementation of model-based control strategies for real time control of crystal size distribution (CSD) in semi batch crystallization processes. The objective of the feedback controller is to reach a desired particle mean size while the standard deviation is controlled in a feed-forward fashion. Alternative model-based control strategies are formulated and implemented for a target mean size. An image processing technique based on wavelet-fractal and energy signature analysis is employed to determine online CSD status for the controller's corrective actions. To validate the proposed model-based control strategies, unseeded crystallization of sodium chloride in water using ethanol as antisolvent is performed in an experimental bench-scale semi-batch crystallizer.

• 出版日期2018-11-23