Gold-Catalyzed Mannich Addition Reactions of 1,3-Dicarbonyl Compounds with N-Protected Imines

作者:Delgado Rebollo Manuela; Moreno Rocio; Fructos Manuel R*; Prieto Auxiliadora
来源:European Journal of Organic Chemistry, 2013, 2013(1): 31-34.
DOI:10.1002/ejoc.201201252

摘要

The first (N-heterocyclic carbene) Au-I-catalyzed Mannich addition reactions of N-protected imines with different 1,3-dicarbonyl compounds are described. IPrAuNTf2 was proven to be an efficient catalyst for the reactions of beta-keto esters and 1,3-diketones with N-sulfonylimines to afford the desired beta-amino carbonyl compounds in good yields under very mild conditions.

  • 出版日期2013-1