A biopharmaceutical plant on a chip: continuous micro-devices for the production of monoclonal antibodies

作者：Garza Garcia Lucia D; Carrillo Cocom Leydi M; Araiz Hernandez Diana; Soto Vazquez Pedro; Lopez Meza Julian; Tapia Mejia Eduardo J; Camacho Leon Sergio; Garcia Lopez Erika; Rodriguez Gonzalez Ciro A; Alvarez Mario M^*

来源：Lab on a Chip, 2013, 13(7): 1243-1246.

DOI：10.1039/c3lc50104c

We report a proof-of-principle for the use of micro-devices as continuous bioreactors for the production of monoclonal antibodies. We culture CHO cells on the surface of PMMA "zigzag'' channels textured with semi-spherical cavities coated with fibronectin, observing steady-state productivities 100 times higher than those observed in full scale systems.

• 出版日期2013