Design, synthesis and biological evaluation of potent NAD(+)-dependent DNA ligase inhibitors as potential antibacterial agents. Part II: 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones

作者：Wang Tiansheng^*; Duncan Leonard; Gu Wenxin; O'Dowd Hardwin; Wei Yunyi; Perola Emanuele; Parsons Jonathan; Gross Christian H; Moody Cameron Stuver; Arends S J Ryan; Charifson Paul S

来源：Bioorganic & Medicinal Chemistry Letters, 2012, 22(11): 3699-3703.

DOI：10.1016/j.bmcl.2012.04.038

• Antibiotics
• NAD
• DNA ligase
• Pyridopyrimidinone
• Inhibitor

A series of 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones were designed and synthesized as a novel class of inhibitors of NAD(+)-dependent DNA ligase that possess potency against Gram-positive bacteria.

• 出版日期2012-6-1