Non-canonical IKKs, IKK epsilon and TBK1, as novel therapeutic targets in the treatment of non-small cell lung cancer

作者：Kim Jae Young; Beg Amer A; Haura Eric B^*

来源：Expert Opinion on Therapeutic Targets, 2013, 17(10): 1109-1112.

DOI：10.1517/14728222.2013.833188

• IKK epsilon
• lung cancer
• NF-kappa B
• TBK1

It is well known that non-canonical I kappa B kinases (IKK), IKK epsilon and Tank-binding kinase 1 (TBK1), play a key role in anti-viral responses. Interestingly, they have recently emerged as novel survival kinases in several human cancers including lung cancer, given their roles in maintaining cancer cell survival and promoting oncogenic transformation. However, the molecular mechanisms by which IKK epsilon/TBK1 are activated and IKK epsilon/TBK1 mediate survival signal in cancer cells are still controversial. This article will briefly describe signaling pathways mediated by these non-canonical IKKs, especially focusing in lung cancer, and discuss their potential as molecular targets for lung cancer treatment.

• 出版日期2013-10