LINGO1 Variants in the French-Canadian Population

作者：Bourassa Cynthia V^*; Riviere Jean Baptiste; Dion Patrick A; Bernard Genevieve; Diab Sabrina; Panisset Michel; Chouinard Sylvain; Dupre Nicolas; Fournier Helene; Raelson John; Belouchi Majid; Rouleau Guy A

来源：PLos One, 2011, 6(1): e16254.

DOI：10.1371/journal.pone.0016254

Essential tremor (ET) is a complex genetic disorder for which no causative gene has been found. Recently, a genome-wide association study reported that two variants in the LINGO1 locus were associated to this disease. The aim of the present study was to test if this specific association could be replicated using a French-Canadian cohort of 259 ET patients and 479 ethnically matched controls. Our genotyping results lead us to conclude that no association exists between the key variant rs9652490 and ET (P(corr) = 1.00).

• 出版日期2011-1-11