Agreement between patients%26apos; self-report and physicians%26apos; prescriptions on nonsteroidal anti-inflammatory drugs and other drugs used in musculoskeletal disorders: the international Pharmacoepidemiologic General Research eXtension database.

作者：Grimaldi Bensouda Lamiae^*; Rossignol Michel; Aubrun Elodie; Benichou Jacques; Abenhaim Lucien

来源：Pharmacoepidemiology and Drug Safety, 2012, 21(7): 753-759.

DOI：10.1002/pds.3194

• patients%26apos
• self-report prescription
• nonsteroidal anti-inflammatory drug
• musculoskeletal disorders

Purpose The use of prescription records for the assessment of exposure to nonsteroidal anti-inflammatory drugs (NSAIDs) does not capture over-the-counter drug use. This study compared patients%26apos; self-reported use to physician%26apos;s prescriptions for NSAIDs and other drugs used to treat musculoskeletal disorders (MSDs). Methods The international Pharmacoepidemiologic General Research eXtension database includes a network of general practitioners recruiting patients without reference to diagnoses or prescriptions. Data on all drug use across France within the 2 years preceding the date of inclusion (index date) were obtained from both patients%26apos; self-reports (PSRs) and physicians%26apos; prescription reports (PPRs). Patients%26apos; reports were obtained using a structured telephone interview combined with an interview guide containing a list of drugs commonly used. Comparisons were made on exposure to four categories of MSD drugs and three time windows up to 24?months before the index date. Results Agreement between physician and patient reports was assessed on 4152 patient-physician pairs. Bias- and prevalence-adjusted kappa values showed fair agreement for nonaspirin NSAIDs, moderate to fair for nonnarcotic analgesics, high for osteoarthritis and moderate to substantial for muscle relaxants. Over-the-counter drug use was associated with greater disagreement (OR?=?2.21, 95%CI?=?1.051.38). Age was not associated with disagreement. Conclusion Differences between PSR and PPR in estimating the prevalence of MSD drug use varied by the type of drug and the elapsed time from the index date. The patient-assisted interview method used in this study showed better agreement with PPR compared with standard interviews, especially for long time windows and patients older than 65?years.

• 出版日期2012-7