Molecular iodine promoted synthesis of new pyrazolo[3,4-d]pyrimidine derivatives as potential antibacterial agents

作者：Bakavoli Mehdi^*; Bagherzadeh Ghodsieh; Vaseghifar Maryam; Shiri Ali; Pordel Mehdi; Mashreghi Mansour; Pordeli Parvaneh; Araghi Maryam

来源：European Journal of Medicinal Chemistry, 2010, 45(2): 647-650.

DOI：10.1016/j.ejmech.2009.10.051

• Pyrazolo[3,4-d]pyrimidine
• Antibacterial agents
• Iodine
• Heterocyclization

Iodocyclization of 5-amino-1-(2,4-dinitrophenyl)-1H-4-pyrazolcarboxamides with aromatic aldehydes gave a new series of pyrazolo[3,4-d]pyrimidine derivatives in a single step and their antibacterial activity comparable to Streptomycin as reference drug was evaluated.

• 出版日期2010-2